Neurodegenerative diseases are incurable debilitating disorders of the nervous system that affect approximately 30 million people worldwide. Despite profuse efforts attempting to define the molecular mechanisms underlying neurodegeneration, many aspects of these pathologies remain elusive. The novelty of their mechanisms represents a challenge to biology, to their related biomarkers identification and drug discovery. Because of their multifactorial aspects and complexity, gene expression analysis plat- forms have been extensively used to investigate altered pathways during degeneration and to identify potential biomarkers and drug targets.

Gene expression profiling and therapeutic interventions in neurodegenerative diseases: a comprehensive study on potentiality and limits / Benetti, F; Gustincich, Stefano; Legname, Giuseppe. - In: EXPERT OPINION ON DRUG DISCOVERY. - ISSN 1746-0441. - 7:3(2012), pp. 245-259. [10.1517/17460441.2012.659661]

Gene expression profiling and therapeutic interventions in neurodegenerative diseases: a comprehensive study on potentiality and limits

Gustincich, Stefano;Legname, Giuseppe
2012-01-01

Abstract

Neurodegenerative diseases are incurable debilitating disorders of the nervous system that affect approximately 30 million people worldwide. Despite profuse efforts attempting to define the molecular mechanisms underlying neurodegeneration, many aspects of these pathologies remain elusive. The novelty of their mechanisms represents a challenge to biology, to their related biomarkers identification and drug discovery. Because of their multifactorial aspects and complexity, gene expression analysis plat- forms have been extensively used to investigate altered pathways during degeneration and to identify potential biomarkers and drug targets.
2012
7
3
245
259
Benetti, F; Gustincich, Stefano; Legname, Giuseppe
File in questo prodotto:
File Dimensione Formato  
Benetti_ExpertOpinDrugDiscov_2012.pdf

non disponibili

Tipologia: Versione Editoriale (PDF)
Licenza: Non specificato
Dimensione 212.21 kB
Formato Adobe PDF
212.21 kB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.11767/12263
Citazioni
  • ???jsp.display-item.citation.pmc??? 6
  • Scopus 18
  • ???jsp.display-item.citation.isi??? 17
social impact