Prion diseases are fatal neurodegenerative disorders caused by an aberrant accumulation of the misfolded cellular prion protein (PrPC) conformer, denoted as infectious scrapie isoform or PrPSc. Our understanding of the mechanisms by which mutations cause disease remains limited. In this work results of recent high-resolution NMR structural studies on human prion protein variants carrying pathological mutations are presented.

NMR studies of human prion proteins with inherited mutations / Biljan, I; Ilc, G; Giachin, G; Legname, Giuseppe; Plavec, J.. - (2011). (Intervento presentato al convegno SISSA/ELETTRA PRION research workshop tenutosi a Trieste).

NMR studies of human prion proteins with inherited mutations

Legname, Giuseppe;
2011-01-01

Abstract

Prion diseases are fatal neurodegenerative disorders caused by an aberrant accumulation of the misfolded cellular prion protein (PrPC) conformer, denoted as infectious scrapie isoform or PrPSc. Our understanding of the mechanisms by which mutations cause disease remains limited. In this work results of recent high-resolution NMR structural studies on human prion protein variants carrying pathological mutations are presented.
2011
4 th SISSA/ELETTRA PRION research workshop : [Trieste, Italy], January 10th, 2011
s.n.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.11767/15539
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