New experimental tools capable of probing the three-dimensional organization of eukaryotic genomes with an unprecedented level of detail have been developed in the last few years. In the quest for a quantitative understanding of experimental results, several polymer models for chromatin organization were introduced and critically evaluated. In the present article, I give a brief introduction to the physical basis of chromosome organization, and recall the experimental evidence in favour of the importance of topological constraints for the description of chromosome conformations in eukaryotes.

Topological constraints and chromosome organization in eukaryotes: a physical point of view / Rosa, Angelo. - In: BIOCHEMICAL SOCIETY TRANSACTIONS. - ISSN 0300-5127. - 41:2(2013), pp. 612-615. [10.1042/BST20120330]

Topological constraints and chromosome organization in eukaryotes: a physical point of view

Rosa, Angelo
2013-01-01

Abstract

New experimental tools capable of probing the three-dimensional organization of eukaryotic genomes with an unprecedented level of detail have been developed in the last few years. In the quest for a quantitative understanding of experimental results, several polymer models for chromatin organization were introduced and critically evaluated. In the present article, I give a brief introduction to the physical basis of chromosome organization, and recall the experimental evidence in favour of the importance of topological constraints for the description of chromosome conformations in eukaryotes.
2013
41
2
612
615
https://doi.org/10.1042/BST20120330
Rosa, Angelo
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.11767/15847
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