miRNAs are essential post-transcriptional modulators affecting cell identity and fate, with a central role in cellular and developmental processes. The brain-enriched neuronal specific miRNAs-124 has been identified as a promoter of neuronogenesis in various conditions, in vitro and in vivo, with a potential role in regulating also activities of post-mitotic neurons, such as synaptic plasticity and memory formation. In this point of view, we recapitulate the main experimental findings substantiating the positive correlation between miR- 124 expression and neuronogenesis progression. Then, we describe the impact of miR-124 on the molecular network driving the profound changes which take place in differentiating neuronal cells. Finally, we consider the possibility of a post- transcriptional modulation of miR-124 biogenesis, which may finely regulate—in turn—the activities of miR-124 in neural precursor cells.
The pro-differentiating role of miR-124: Indicating the road to become a neuron / Maiorano, N. A.; Mallamaci, A.. - In: RNA BIOLOGY. - ISSN 1547-6286. - 7:5(2010), pp. 528-533. [10.4161/rna.7.5.12262]
The pro-differentiating role of miR-124: Indicating the road to become a neuron
Mallamaci, A.
2010-01-01
Abstract
miRNAs are essential post-transcriptional modulators affecting cell identity and fate, with a central role in cellular and developmental processes. The brain-enriched neuronal specific miRNAs-124 has been identified as a promoter of neuronogenesis in various conditions, in vitro and in vivo, with a potential role in regulating also activities of post-mitotic neurons, such as synaptic plasticity and memory formation. In this point of view, we recapitulate the main experimental findings substantiating the positive correlation between miR- 124 expression and neuronogenesis progression. Then, we describe the impact of miR-124 on the molecular network driving the profound changes which take place in differentiating neuronal cells. Finally, we consider the possibility of a post- transcriptional modulation of miR-124 biogenesis, which may finely regulate—in turn—the activities of miR-124 in neural precursor cells.File | Dimensione | Formato | |
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