Ca(2+)-activated Cl(-) currents have been implicated in many cellular processes in different cells, but for many years, their molecular identity remained unknown. Particularly intriguing are Ca(2+)-activated Cl(-) currents in olfactory transduction, first described in the early 90s. Well characterized electrophysiologically, they carry most of the odorant-induced receptor current in the cilia of olfactory sensory neurons (OSNs). After many attempts to determine their molecular identity, TMEM16B was found to be abundantly expressed in the cilia of OSNs in 2009 and having biophysical properties like those of the native olfactory channel. A TMEM16B knock-out mouse confirmed that TMEM16B was indeed the olfactory Cl(-) channel but also suggested a limited role in olfactory physiology and behavior. The question then arises of what the precise role of TMEM16b in olfaction is. Here we review the long story of this channel and its possible roles. © 2017 Taylor & Francis

The long tale of the calcium activated Cl(-) Channels in olfactory transduction / Dibattista, Michele; Pifferi, Simone; Boccaccio, Anna Elisabetta; Menini, Anna; Reisert, Johannes. - In: CHANNELS. - ISSN 1933-6950. - 11:5(2017), pp. 399-414. [10.1080/19336950.2017.1307489]

The long tale of the calcium activated Cl(-) Channels in olfactory transduction

Pifferi, Simone;Boccaccio, Anna Elisabetta;Menini, Anna;
2017-01-01

Abstract

Ca(2+)-activated Cl(-) currents have been implicated in many cellular processes in different cells, but for many years, their molecular identity remained unknown. Particularly intriguing are Ca(2+)-activated Cl(-) currents in olfactory transduction, first described in the early 90s. Well characterized electrophysiologically, they carry most of the odorant-induced receptor current in the cilia of olfactory sensory neurons (OSNs). After many attempts to determine their molecular identity, TMEM16B was found to be abundantly expressed in the cilia of OSNs in 2009 and having biophysical properties like those of the native olfactory channel. A TMEM16B knock-out mouse confirmed that TMEM16B was indeed the olfactory Cl(-) channel but also suggested a limited role in olfactory physiology and behavior. The question then arises of what the precise role of TMEM16b in olfaction is. Here we review the long story of this channel and its possible roles. © 2017 Taylor & Francis
2017
11
5
399
414
https://www.ncbi.nlm.nih.gov/pubmed/?term=The+long+tale+of+the+calcium+activated+in+olfactory+transduction
Dibattista, Michele; Pifferi, Simone; Boccaccio, Anna Elisabetta; Menini, Anna; Reisert, Johannes
File in questo prodotto:
File Dimensione Formato  
Dibattista_Channel_17.pdf

Open Access dal 17/03/2018

Tipologia: Documento in Post-print
Licenza: Non specificato
Dimensione 1.31 MB
Formato Adobe PDF
1.31 MB Adobe PDF Visualizza/Apri

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.11767/40667
Citazioni
  • ???jsp.display-item.citation.pmc??? 20
  • Scopus 42
  • ???jsp.display-item.citation.isi??? 35
social impact