TRPA1 is an ion channel expressed by nociceptors and activated by irritant compounds such as mustard oil. The endogenous function of TRPA1 has remained unclear, a fact highlighted by ongoing debate over its potential role as a sensor of noxious cold. Here we show that intracellular Ca2+ activates human TRPA1 via an EF-hand domain and that cold sensitivity occurs indirectly (and nonphysiologically) through increased [Ca2+] i during cooling in heterologous systems. © 2007 Nature Publishing Group.
Direct activation of the ion channel TRPA1 by Ca2+ / Zurborg, Sandra; Yurgionas, Brian; Jira, Julia A; Caspani, Ombretta; Heppenstall, Paul A.. - In: NATURE NEUROSCIENCE. - ISSN 1097-6256. - 10:3(2007), pp. 277-279. [10.1038/nn1843]
Direct activation of the ion channel TRPA1 by Ca2+
Heppenstall, Paul A.
2007-01-01
Abstract
TRPA1 is an ion channel expressed by nociceptors and activated by irritant compounds such as mustard oil. The endogenous function of TRPA1 has remained unclear, a fact highlighted by ongoing debate over its potential role as a sensor of noxious cold. Here we show that intracellular Ca2+ activates human TRPA1 via an EF-hand domain and that cold sensitivity occurs indirectly (and nonphysiologically) through increased [Ca2+] i during cooling in heterologous systems. © 2007 Nature Publishing Group.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
