Over the years, advances in experimental and computational methods have helped us to understand the role of thermodynamic, kinetic and active (chaperone-aided) effects in coordinating the folding steps required to achieving a knotted native state. Here, we review such developments by paying particular attention to the complementarity of experimental and computational studies. Key open issues that could be tackled with either or both approaches are finally pointed out. © 2016 Elsevier Ltd

How to fold intricately: using theory and experiments to unravel the properties of knotted proteins / Jackson, S. E.; Suma, Antonio; Micheletti, Cristian. - In: CURRENT OPINION IN STRUCTURAL BIOLOGY. - ISSN 0959-440X. - 42:Feb(2017), pp. 6-14. [10.1016/j.sbi.2016.10.002]

How to fold intricately: using theory and experiments to unravel the properties of knotted proteins

Suma, Antonio;Micheletti, Cristian
2017-01-01

Abstract

Over the years, advances in experimental and computational methods have helped us to understand the role of thermodynamic, kinetic and active (chaperone-aided) effects in coordinating the folding steps required to achieving a knotted native state. Here, we review such developments by paying particular attention to the complementarity of experimental and computational studies. Key open issues that could be tackled with either or both approaches are finally pointed out. © 2016 Elsevier Ltd
2017
https://arxiv.org/abs/1610.05779
http://cdsads.u-strasbg.fr/abs/2016arXiv161005779J
Jackson, S. E.; Suma, Antonio; Micheletti, Cristian
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.11767/39551
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