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Mechanisms of Glioblastoma Replication: Ca2+ Flares and Cl− Currents

Glioblastoma (GBM) is amongst the deadliest types of cancers, with no resolutive cure currently available. GBM cell proliferation in the patient's brain is a complex phenomenon controlled by multiple mechanisms. The aim of this study was to determine whether the ionic fluxes controlling cell duplication could represent a target for GBM therapy. In this work, we combined multi-channel Ca2+ and Cl- imaging, optical tweezers, electrophysiology, and immunohistochemistry to describe the role of io...

The Ca2+-activated Cl- channel TMEM16B shapes the response time course of olfactory sensory neurons

Mammalian olfactory sensory neurons (OSNs) generate an odorant-induced response by sequentially activating two ion channels, which are in their ciliary membranes. First, a cationic, Ca2+-permeable cyclic nucleotide-gated channel is opened following odorant stimulation via a G protein-coupled transduction cascade and an ensuing rise in cAMP. Second, the increase in ciliary Ca2+ opens the excitatory Ca2+-activated Cl- channel TMEM16B, which carries most of the odorant-induced receptor current. ...

Exosomal TNF-α mediates voltage-gated Na+ channel 1.6 overexpression and contributes to brain tumor–induced neuronal hyperexcitability

Patients affected by glioma frequently experience epileptic discharges; however, the causes of brain tumor–related epilepsy (BTRE) are still not completely understood. We investigated the mechanisms underlying BTRE by analyzing the effects of exosomes released by U87 glioma cells and by patient-derived glioma cells. Rat hippocampal neurons incubated for 24 hours with these exosomes exhibited increased spontaneous firing, while their resting membrane potential shifted positively by 10–15 mV. V...

Integrable operators, ∂ ― -problems, KP and NLS hierarchy

We develop the theory of integrable operators K acting on a domain of the complex plane with smooth boundary in analogy with the theory of integrable operators acting on contours of the complex plane. We show how the resolvent operator is obtained from the solution of a partial derivative -problem in the complex plane. When such a partial derivative -problem depends on auxiliary parameters we define its Malgrange one form in analogy with the theory of isomonodromic problems. We show that the ...

The Stieltjes–Fekete Problem and Degenerate Orthogonal Polynomials

A result of Stieltjes famously relates the zeroes of the classical orthogonal polynomials with the configurations of points on the line that minimize a suitable energy with logarithmic interactions under an external field. The optimal configuration satisfies an algebraic set of equations: we call this set of algebraic equations the Stieltjes-Fekete problem. In this work we consider the Stieltjes-Fekete problem when the derivative of the external field is an arbitrary rational complex function...

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Tipologia
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Autore
  • Baccigalupi, Carlo358
  • Legname, Giuseppe355
  • Danese, Luigi321
  • Bressan, Alessandro261
  • Calabrese, Pasquale254
  • Viel, Matteo245
  • Lapi, Andrea230
  • Baroni, Stefano226
  • Liberati, Stefano216
  • Rozza, Gianluigi209
Data di pubblicazione
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  • 2020 - 20242316
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  • NUCLEAR PHYSICS. B193
  • PHYSICS LETTERS. SECTION B177
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Settore disciplinare
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