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Oxidative stress‐related cellular aging causes dysfunction of the Kv3.1/KCNC1 channel reverted by melatonin

The voltage-gated Kv3.1/KCNC1 channel is abundantly expressed in fast-spiking principal neurons and GABAergic inhibitory interneurons throughout the ascending auditory pathway and in various brain regions. Inactivating mutations in the KCNC1 gene lead to forms of epilepsy and a decline in the expression of the Kv3.1 channel is involved in age-related hearing loss. As oxidative stress plays a fundamental role in the pathogenesis of epilepsy and age-related hearing loss, we hypothesized that an...

Tau seeding activity in skin biopsy differentiates tauopathies from synucleinopathies

Most neurodegenerative diseases lack definitive diagnostic tests, and the identification of easily accessible and reliable biomarkers remains a critical unmet need. Since tau protein is highly expressed in skin of tauopathies patients, we aimed to exploit the ultrasensitive seeding activity assay (SAA) to assess tau seeding activity in skin of patients with tauopathies. In this multicentric, case-control study, patients with tauopathies and synucleinopathies were consecutively recruited and s...

Comparing Prion Proteins Across Species: Is Zebrafish a Useful Model?

Despite the considerable body of research dedicated to the field of neurodegeneration, the gap in knowledge on the prion protein and its intricate involvement in brain diseases remains substantial. However, in the past decades, many steps forward have been taken toward a better understanding of the molecular mechanisms underlying both the physiological role of the prion protein and the misfolding event converting it into its pathological counterpart, the prion. This review aims to provide an ...

Transmission of Norwegian reindeer CWD to sheep by intracerebral inoculation results in an unusual phenotype and prion distribution

Chronic wasting disease (CWD), a prion disease affecting cervids, has been known in North America (NA) since the 1960s and emerged in Norway in 2016. Surveillance and studies have revealed that there are different forms of CWD in Fennoscandia: contagious CWD in Norwegian reindeer and sporadic CWD in moose and red deer. Experimental studies have demonstrated that NA CWD prions can infect various species, but thus far, there have been no reports of natural transmission to non-cervid species. In...

Prion protein alters viral control and enhances pathology after perinatal cytomegalovirus infection

Cytomegalovirus (CMV) infection poses risks to newborns, necessitating effective therapies. Given that the damage includes both viral infection of brain cells and immune system-related damage, here we investigate the involvement of cellular prion protein (PrP), which plays vital roles in neuroprotection and immune regulation. Using a murine model, we show the role of PrP in tempering neonatal T cell immunity during CMV infection. PrP-null mice exhibit enhanced viral control through elevated v...

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Tipologia
  • 1 Article10488
  • 8 Thesis2348
  • 4 Conference object751
  • 2 Book part326
  • 3 Book62
  • 5 Other25
  • 6 Patent21
  • 7 Trusteeship14
Autore
  • Baccigalupi, Carlo362
  • Legname, Giuseppe362
  • Danese, Luigi321
  • Bressan, Alessandro262
  • Calabrese, Pasquale255
  • Viel, Matteo247
  • Lapi, Andrea233
  • Baroni, Stefano227
  • Liberati, Stefano221
  • Rozza, Gianluigi214
Data di pubblicazione
  • In corso di stampa17
  • 2020 - 20252730
  • 2010 - 20195385
  • 2000 - 20093506
  • 1990 - 19991686
  • 1980 - 1989621
  • 1970 - 197976
  • 1962 - 196914
Editore
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  • Springer121
  • World Scientific46
  • Elsevier22
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  • Oxford University Press19
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  • American Institute of Physics13
  • IEEE13
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Rivista
  • JOURNAL OF HIGH ENERGY PHYSICS472
  • MONTHLY NOTICES OF THE ROYAL ASTR...445
  • ASTRONOMY & ASTROPHYSICS407
  • PHYSICAL REVIEW LETTERS386
  • PHYSICAL REVIEW. B, CONDENSED MAT...339
  • THE ASTROPHYSICAL JOURNAL238
  • JOURNAL OF COSMOLOGY AND ASTROPAR...228
  • PHYSICAL REVIEW D, PARTICLES, FIE...197
  • NUCLEAR PHYSICS. B194
  • PHYSICAL REVIEW. B194
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  • LECTURE NOTES IN COMPUTER SCIENCE7
  • PROCEEDINGS OF THE IEEE CONFERENC...7
  • SPRINGER INDAM SERIES6
  • ADVANCES IN NEURAL INFORMATION PR...5
Settore disciplinare
  • Settore FIS/05 - Astronomia e Ast...1994
  • Settore FIS/03 - Fisica della Mat...1745
  • Settore FIS/02 - Fisica Teorica, ...1594
  • Settore MAT/05 - Analisi Matematica758
  • Settore BIO/09 - Fisiologia541
  • Settore MAT/07 - Fisica Matematica530
  • Settore M-PSI/02 - Psicobiologia ...409
  • Settore MAT/08 - Analisi Numerica327
  • Settore MAT/03 - Geometria269
  • Settore BIO/13 - Biologia Applicata155
Keyword
  • Humans135
  • Animals104
  • Cosmic background radiation87
  • dark matter80
  • High Energy Physics - Theory79
  • Cosmology: observations78
  • Astronomy and Astrophysics72
  • General Relativity and Quantum Co...72
  • galaxies: evolution71
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