Background: Patients affected by a high-grade glioma (HGG) have a poor prognosis with a median survival of 12-16 months. Such poor prognosis affects the perception of the remaining life by patients and the neuropsychological status can strongly affect every-day functioning of these patients. Monitoring changes of neuropsychological functioning (NPF) over time may provide better clinical information and optimize the neuro-oncological management. Aims of our work were: 1) to investigate the feasibility of a complex neuropsychological battery in HGG patients before and during follow-up after surgery; 2) to study the neuropsychological profile of patients affected by HGGs and their relation with the disease status (relapse/death) across time after surgery. Methods: 102 patients who received surgery for HGG between 2011 and 2017 were studied. All clinical data were prospectively recorded. NPF was assessed during the neuro-oncological follow-up through the Milano-Bicocca Battery (MIBIB). Statistical analysis was performed on the neuropsychological results of the tests administered. Results: First, MIBIB proved to be suitable for patients with HGG tumors before and after surgery, and during long-term follow-up; it also showed a cluster structure representative of the principal cognitive domains. Second, we found a steep decline in the neuropsychological profile before death and/or tumor relapse for the 52% of the neuropsychological tests administered. Conclusion: Complex neuropsychological batteries can be administered to HGG patients before and during follow-up after surgery. There is a correlation between neuropsychological deterioration and tumor relapse and/or death, which may reflect a progressive damage to cognitive functions due to tumor infiltration and progression.

Long term follow–up of neuropsychological functions in patients with high grade gliomas: can cognitive status predict patient’s outcome after surgery? / Zarino, Barbara; Di Cristofori, Andrea; Fornara, Giorgia Abete; Bertani, Giulio Andrea; Locatelli, Marco; Caroli, Manuela; Rampini, Paolo; Cogiamanian, Filippo; Crepaldi, Davide; Carrabba, Giorgio. - In: ACTA NEUROCHIRURGICA. - ISSN 0001-6268. - 162:4(2020), pp. 803-812. [10.1007/s00701-020-04230-y]

Long term follow–up of neuropsychological functions in patients with high grade gliomas: can cognitive status predict patient’s outcome after surgery?

Crepaldi, Davide;
2020

Abstract

Background: Patients affected by a high-grade glioma (HGG) have a poor prognosis with a median survival of 12-16 months. Such poor prognosis affects the perception of the remaining life by patients and the neuropsychological status can strongly affect every-day functioning of these patients. Monitoring changes of neuropsychological functioning (NPF) over time may provide better clinical information and optimize the neuro-oncological management. Aims of our work were: 1) to investigate the feasibility of a complex neuropsychological battery in HGG patients before and during follow-up after surgery; 2) to study the neuropsychological profile of patients affected by HGGs and their relation with the disease status (relapse/death) across time after surgery. Methods: 102 patients who received surgery for HGG between 2011 and 2017 were studied. All clinical data were prospectively recorded. NPF was assessed during the neuro-oncological follow-up through the Milano-Bicocca Battery (MIBIB). Statistical analysis was performed on the neuropsychological results of the tests administered. Results: First, MIBIB proved to be suitable for patients with HGG tumors before and after surgery, and during long-term follow-up; it also showed a cluster structure representative of the principal cognitive domains. Second, we found a steep decline in the neuropsychological profile before death and/or tumor relapse for the 52% of the neuropsychological tests administered. Conclusion: Complex neuropsychological batteries can be administered to HGG patients before and during follow-up after surgery. There is a correlation between neuropsychological deterioration and tumor relapse and/or death, which may reflect a progressive damage to cognitive functions due to tumor infiltration and progression.
162
4
803
812
https://link.springer.com/article/10.1007/s00701-020-04230-y
Zarino, Barbara; Di Cristofori, Andrea; Fornara, Giorgia Abete; Bertani, Giulio Andrea; Locatelli, Marco; Caroli, Manuela; Rampini, Paolo; Cogiamanian, Filippo; Crepaldi, Davide; Carrabba, Giorgio
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.11767/106927
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