Epidural electrical spinal stimulation can facilitate recovery of volitional motor control in individuals that have been completely paralyzed for more than a year. We recently reported a novel neuromodulation method named Dynamic Stimulation (DS), which short-lastingly increased spinal excitability and generated a robust modulation of locomotor networks in fully-anesthetized intact adult rats. In the present study, we applied repetitive DS patterns to four lumbosacral segments acutely after a contusive injury at lumbar level. Repetitive DS delivery restored the spinally-evoked motor EMG responses that were previously suppressed by a calibrated spinal cord contusion. Sham experiments without DS delivery did not allow any spontaneous recovery. Thus, DS uniquely provides the potential for a greater long-term functional recovery after paralysis.
Acute neuromodulation restores spinally-induced motor responses after severe spinal cord injury / Taccola, G.; Gad, P.; Culaclii, S.; Wang, P. M.; Liu, W.; Edgerton, V. R.. - In: EXPERIMENTAL NEUROLOGY. - ISSN 0014-4886. - 327:(2020). [10.1016/j.expneurol.2020.113246]
Acute neuromodulation restores spinally-induced motor responses after severe spinal cord injury
Taccola, G.
;
2020-01-01
Abstract
Epidural electrical spinal stimulation can facilitate recovery of volitional motor control in individuals that have been completely paralyzed for more than a year. We recently reported a novel neuromodulation method named Dynamic Stimulation (DS), which short-lastingly increased spinal excitability and generated a robust modulation of locomotor networks in fully-anesthetized intact adult rats. In the present study, we applied repetitive DS patterns to four lumbosacral segments acutely after a contusive injury at lumbar level. Repetitive DS delivery restored the spinally-evoked motor EMG responses that were previously suppressed by a calibrated spinal cord contusion. Sham experiments without DS delivery did not allow any spontaneous recovery. Thus, DS uniquely provides the potential for a greater long-term functional recovery after paralysis.File | Dimensione | Formato | |
---|---|---|---|
Taccola et al._Exp Neurol_2020.pdf
Open Access dal 13/02/2021
Descrizione: Postprint
Tipologia:
Documento in Post-print
Licenza:
Creative commons
Dimensione
505.86 kB
Formato
Adobe PDF
|
505.86 kB | Adobe PDF | Visualizza/Apri |
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.