The regrowth of severed axons is fundamental to reestablish motor control after spinal-cord injury (SCI). Ongoing efforts to promote axonal regeneration after SCI have involved multiple strategies that have been only partially successful. Our study introduces an artificial carbon-nanotube based scaffold that, once implanted in SCI rats, improves motor function recovery. Confocal microscopy analysis plus fiber tracking by magnetic resonance imaging and neurotracer labeling of long-distance corticospinal axons suggest that recovery might be partly attributable to successful crossing of the lesion site by regenerating fibers. Since manipulating SCI microenvironment properties, such as mechanical and electrical ones, may promote biological responses, we propose this artificial scaffold as a prototype to exploit the physics governing spinal regenerative plasticity.

Functional rewiring across spinal injuries via biomimetic nanofiber scaffolds / Usmani, Sadaf; Franceschi Biagioni, Audrey; Medelin, Manuela; Scaini, Denis; Casani, Raffaele; Aurand, Emily R; Padro, Daniel; Egimendia, Ander; Ramos Cabrer, Pedro; Scarselli, Manuela; De Crescenzi, Maurizio; Prato, Maurizio; Ballerini, Laura. - In: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. - ISSN 0027-8424. - 117:41(2020), pp. 25212-25218. [10.1073/pnas.2005708117]

Functional rewiring across spinal injuries via biomimetic nanofiber scaffolds

Usmani, Sadaf;Franceschi Biagioni, Audrey;Medelin, Manuela;Scaini, Denis;Casani, Raffaele;Ballerini, Laura
2020

Abstract

The regrowth of severed axons is fundamental to reestablish motor control after spinal-cord injury (SCI). Ongoing efforts to promote axonal regeneration after SCI have involved multiple strategies that have been only partially successful. Our study introduces an artificial carbon-nanotube based scaffold that, once implanted in SCI rats, improves motor function recovery. Confocal microscopy analysis plus fiber tracking by magnetic resonance imaging and neurotracer labeling of long-distance corticospinal axons suggest that recovery might be partly attributable to successful crossing of the lesion site by regenerating fibers. Since manipulating SCI microenvironment properties, such as mechanical and electrical ones, may promote biological responses, we propose this artificial scaffold as a prototype to exploit the physics governing spinal regenerative plasticity.
117
41
25212
25218
https://www.pnas.org/content/117/41/25212
Usmani, Sadaf; Franceschi Biagioni, Audrey; Medelin, Manuela; Scaini, Denis; Casani, Raffaele; Aurand, Emily R; Padro, Daniel; Egimendia, Ander; Ramos Cabrer, Pedro; Scarselli, Manuela; De Crescenzi, Maurizio; Prato, Maurizio; Ballerini, Laura
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/20.500.11767/114775
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