Individual medial entorhinal cortex (mEC) 'grid' cells provide a representation of space that appears to be essentially invariant across environments, modulo simple transformations, in contrast to multiple, rapidly acquired hippocampal maps; it may therefore be established gradually during rodent development. We explore with a simplified mathematical model the possibility that the self-organization of multiple grid fields into a triangular grid pattern may be a single-cell process, driven by firing rate adaptation and slowly varying spatial inputs. A simple analytical derivation indicates that triangular grids are favored asymptotic states of the self-organizing system, and computer simulations confirm that such states are indeed reached during a model learning process, provided it is sufficiently slow to effectively average out fluctuations. The interactions among local ensembles of grid units serve solely to stabilize a common grid orientation. Spatial information, in the real mEC network, may be provided by any combination of feed-forward cortical afferents and feedback hippocampal projections from place cells, since either input alone is likely sufficient to yield grid fields.
|Titolo:||The emergence of grid cells: Intelligent design or just adaptation?|
|Autori:||Kropff, E.; Treves, A.|
|Data di pubblicazione:||2008|
|Digital Object Identifier (DOI):||10.1002/hipo.20520|
|Fulltext via DOI:||10.1002/hipo.20520|
|Appare nelle tipologie:||1.1 Journal article|