The interplay between cellular growth and cell-cell signaling is essential for the aggregation and proliferation of bacterial colonies, as well as for the self-organization of cell tissues. To investigate this interplay, we focus here on the collective properties of dividing chemotactic cell colonies by studying their long-time and large-scale dynamics through a renormalization group (RG) approach. The RG analysis reveals that a relevant but unconventional chemotactic interaction corresponding to a polarity induced mechanism is generated by fluctuations at macroscopic scales, even when an underlying mechanism is absent at the microscopic level. This emerges from the interplay of the well-known Keller-Segel (KS) chemotactic nonlinearity and cell birth and death processes. At one-loop order, we find no stable fixed point of the RG flow equations. We discuss a connection between the dynamics investigated here and the celebrated Kardar-Parisi-Zhang (KPZ) equation with long-range correlated noise, which points at the existence of a strong-coupling, nonperturbative fixed point. Copyright (C) 2022 EPLA

Stochastic dynamics of chemotactic colonies with logistic growth / Ben Ali Zinati, R.; Duclut, Charlie; Mahdisoltani, Saeed; Gambassi, Andrea; Golestanian, Ramin. - In: EUROPHYSICS LETTERS. - ISSN 0295-5075. - 136:5(2021), pp. 1-7. [10.1209/0295-5075/ac48c9]

Stochastic dynamics of chemotactic colonies with logistic growth

Ben Ali Zinati, R.;Duclut, Charlie;Gambassi, Andrea;
2021-01-01

Abstract

The interplay between cellular growth and cell-cell signaling is essential for the aggregation and proliferation of bacterial colonies, as well as for the self-organization of cell tissues. To investigate this interplay, we focus here on the collective properties of dividing chemotactic cell colonies by studying their long-time and large-scale dynamics through a renormalization group (RG) approach. The RG analysis reveals that a relevant but unconventional chemotactic interaction corresponding to a polarity induced mechanism is generated by fluctuations at macroscopic scales, even when an underlying mechanism is absent at the microscopic level. This emerges from the interplay of the well-known Keller-Segel (KS) chemotactic nonlinearity and cell birth and death processes. At one-loop order, we find no stable fixed point of the RG flow equations. We discuss a connection between the dynamics investigated here and the celebrated Kardar-Parisi-Zhang (KPZ) equation with long-range correlated noise, which points at the existence of a strong-coupling, nonperturbative fixed point. Copyright (C) 2022 EPLA
2021
136
5
1
7
50003
https://arxiv.org/abs/2111.08508
Ben Ali Zinati, R.; Duclut, Charlie; Mahdisoltani, Saeed; Gambassi, Andrea; Golestanian, Ramin
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.11767/131816
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