Alzheimer's disease (AD) is the most common form of dementia among the elderly. Research in the AD field has been mostly focused on the biology of the Aβ peptide but increasing evidence is shifting attention toward the physiological role of APP as key to understanding AD pathology. It is becoming apparent that APP plays a central role in the mechanisms that guarantee the accuracy and the robustness of brain wiring. In the present review we explore APP functions with focus on some of the underlying molecular mechanisms.
Beyond pathology: APP, brain development and Alzheimer's disease / Soldano, Alessia; Hassan, Bassem A. - In: CURRENT OPINION IN NEUROBIOLOGY. - ISSN 0959-4388. - 27:(2014), pp. 61-67. [10.1016/j.conb.2014.02.003]
Beyond pathology: APP, brain development and Alzheimer's disease
Soldano, Alessia;
2014-01-01
Abstract
Alzheimer's disease (AD) is the most common form of dementia among the elderly. Research in the AD field has been mostly focused on the biology of the Aβ peptide but increasing evidence is shifting attention toward the physiological role of APP as key to understanding AD pathology. It is becoming apparent that APP plays a central role in the mechanisms that guarantee the accuracy and the robustness of brain wiring. In the present review we explore APP functions with focus on some of the underlying molecular mechanisms.| File | Dimensione | Formato | |
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