We consider models of Ran-driven nuclear transport of molecules such as proteins in living cells. The mathematical model presented is the first to take into account for the active transport of molecules along the cytoplasmic microtubules. All parameters entering the models are thoroughly discussed. The model is tested by numerical simulations based on discontinuous Galerkin finite element methods. The numerical experiments are compared to the behavior observed experimentally. © 2010 Elsevier Ltd.

A spatial model of cellular molecular trafficking including active transport along microtubules / Cangiani, A.; Natalini, R.. - In: JOURNAL OF THEORETICAL BIOLOGY. - ISSN 0022-5193. - 267:4(2010), pp. 614-625. [10.1016/j.jtbi.2010.08.017]

A spatial model of cellular molecular trafficking including active transport along microtubules

Cangiani A.;Natalini R.
2010-01-01

Abstract

We consider models of Ran-driven nuclear transport of molecules such as proteins in living cells. The mathematical model presented is the first to take into account for the active transport of molecules along the cytoplasmic microtubules. All parameters entering the models are thoroughly discussed. The model is tested by numerical simulations based on discontinuous Galerkin finite element methods. The numerical experiments are compared to the behavior observed experimentally. © 2010 Elsevier Ltd.
2010
267
4
614
625
Cangiani, A.; Natalini, R.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.11767/135255
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