In this work we address the issue of validating the monodomain equation used in combination with the Bueno-Orovio ionic model for the prediction of the activation times in cardiac electro-physiology of the left ventricle. To this aim, we consider four patients who suffered from Left Bundle Branch Block (LBBB). We use activation maps performed at the septum as input data for the model and maps at the epicardial veins for the validation. In particular, a first set (half) of the latter are used to estimate the conductivities of the patient and a second set (the remaining half) to compute the errors of the numerical simulations. We find an excellent agreement between measures and numerical results. Our validated computational tool could be used to accurately predict activation times at the epicardial veins with a short mapping, i.e. by using only a part (the most proximal) of the standard acquisition points, thus reducing the invasive procedure and exposure to radiation.

Integration of activation maps of epicardial veins in computational cardiac electrophysiology / Stella, Simone; Vergara, Christian; Maines, Massimiliano; Catanzariti, Domenico; Africa, Pasquale Claudio; Demattè, Cristina; Centonze, Maurizio; Nobile, Fabio; Del Greco, Maurizio; Quarteroni, Alfio. - In: COMPUTERS IN BIOLOGY AND MEDICINE. - ISSN 0010-4825. - 127:(2020). [10.1016/j.compbiomed.2020.104047]

Integration of activation maps of epicardial veins in computational cardiac electrophysiology

Africa, Pasquale Claudio;Quarteroni, Alfio
2020-01-01

Abstract

In this work we address the issue of validating the monodomain equation used in combination with the Bueno-Orovio ionic model for the prediction of the activation times in cardiac electro-physiology of the left ventricle. To this aim, we consider four patients who suffered from Left Bundle Branch Block (LBBB). We use activation maps performed at the septum as input data for the model and maps at the epicardial veins for the validation. In particular, a first set (half) of the latter are used to estimate the conductivities of the patient and a second set (the remaining half) to compute the errors of the numerical simulations. We find an excellent agreement between measures and numerical results. Our validated computational tool could be used to accurately predict activation times at the epicardial veins with a short mapping, i.e. by using only a part (the most proximal) of the standard acquisition points, thus reducing the invasive procedure and exposure to radiation.
2020
127
104047
https://arxiv.org/abs/2102.00498
Stella, Simone; Vergara, Christian; Maines, Massimiliano; Catanzariti, Domenico; Africa, Pasquale Claudio; Demattè, Cristina; Centonze, Maurizio; Nobile, Fabio; Del Greco, Maurizio; Quarteroni, Alfio
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.11767/135355
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