Carbon nanotubes are increasingly employed in basic neuroscience approaches, and they have been used in the design of neuronal interfaces or in that of scaffolds promoting neuronal growth in vitro. Ultimately, carbon nanotubes are thought to hold the potential for the development of innovative neurological implants. In this framework, it is particularly relevant to document the impact of interfacing such materials with nerve cells. Carbon nanotubes were shown, when modified with biologically active compounds or functionalized in order to alter their charge, to affect neurite outgrowth and branching. Notably, purified carbon nanotubes used as scaffolds can promote the formation of nanotube−neuron hybrid networks, able per se to affect neuron integrative abilities, network connectivity, and synaptic plasticity. We focus this review on our work over several years directed to investigate the ability of carbon nanotube platforms in providing a new tool for non genetic manipulations of neuronal performance and network signaling. © 2012 American Chemical Society.
|Titolo:||Carbon Nanotubes: Artificial Nanomaterials to Engineer Single Neurons and Neuronal Networks|
|Autori:||Fabbro, A.; Bosi, S.; Ballerini, L.; Prato, M.|
|Rivista:||ACS CHEMICAL NEUROSCIENCE|
|Data di pubblicazione:||2012|
|Digital Object Identifier (DOI):||10.1021/cn300048q|
|Appare nelle tipologie:||1.1 Journal article|