We present a numerical characterization of the statics and dynamics of the packaging of a semi-flexiblepolymer inside a sphere. The study is motivated by recent experiments on the packaging of DNAfilaments inside viral capsids. It is found that the force required to confine the coarse-grained polymer isin fair agreement with that found in experiments on the packaging of the phi29 bacteriophage genome.Despite its schematic nature, the model is capable of reproducing the most salient dynamical features ofpackaging experiments such as the presence of pauses during individual packaging processes and theoverall shape of the resisting force as a function of chain packed fraction.

A coarse grained model for DNA and polymer packaging: statics and dynamics / Ali, I.; Marenduzzo, D.; Micheletti, C.; Yeomans, J. M.. - In: JOURNAL OF THEORETICAL MEDICINE. - ISSN 1027-3662. - 6:(2005), pp. 115-117. [10.1080/10273660500149927]

A coarse grained model for DNA and polymer packaging: statics and dynamics

Micheletti C.;
2005-01-01

Abstract

We present a numerical characterization of the statics and dynamics of the packaging of a semi-flexiblepolymer inside a sphere. The study is motivated by recent experiments on the packaging of DNAfilaments inside viral capsids. It is found that the force required to confine the coarse-grained polymer isin fair agreement with that found in experiments on the packaging of the phi29 bacteriophage genome.Despite its schematic nature, the model is capable of reproducing the most salient dynamical features ofpackaging experiments such as the presence of pauses during individual packaging processes and theoverall shape of the resisting force as a function of chain packed fraction.
2005
6
115
117
Ali, I.; Marenduzzo, D.; Micheletti, C.; Yeomans, J. M.
File in questo prodotto:
File Dimensione Formato  
JTM_2005.pdf

non disponibili

Licenza: Non specificato
Dimensione 1.23 MB
Formato Adobe PDF
1.23 MB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.11767/14905
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 3
  • ???jsp.display-item.citation.isi??? ND
social impact