The gene expression response of yeast to various types of stresses/perturbations shows a common functional and dynamical pattern for the vast majority of genes, characterised by a quick transient peak (affecting primarily short genes) followed by a return to the pre-stimulus level. Kinetically, this process of adaptation following the transient excursion can be modelled using a genome-wide autoregulatory mechanism by means of which yeast aims at maintaining a preferential concentration in its mRNA levels. The resulting feedback system explains well the different time constants observable in the transient response, while being in agreement with all the known experimental dynamical features. For example, it suggests that a very rapid transient can be induced also by a slowly varying concentration of the gene products.

Adaptation as a genome-wide autoregulatory principle in the stress response of yeast / G., DE PALO; F., Eduati; M., Zampieri; B., DI CAMILLO; G., Toffolo; Altafini, Claudio. - In: IET SYSTEMS BIOLOGY. - ISSN 1751-8849. - 5:4(2011), pp. 269-279. [10.1049/iet-syb.2009.0050]

Adaptation as a genome-wide autoregulatory principle in the stress response of yeast

Altafini, Claudio
2011

Abstract

The gene expression response of yeast to various types of stresses/perturbations shows a common functional and dynamical pattern for the vast majority of genes, characterised by a quick transient peak (affecting primarily short genes) followed by a return to the pre-stimulus level. Kinetically, this process of adaptation following the transient excursion can be modelled using a genome-wide autoregulatory mechanism by means of which yeast aims at maintaining a preferential concentration in its mRNA levels. The resulting feedback system explains well the different time constants observable in the transient response, while being in agreement with all the known experimental dynamical features. For example, it suggests that a very rapid transient can be induced also by a slowly varying concentration of the gene products.
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G., DE PALO; F., Eduati; M., Zampieri; B., DI CAMILLO; G., Toffolo; Altafini, Claudio
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/20.500.11767/29986
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