GABA-mediated transmission is characterized by high variability of synaptic responses. Major contributors to this variability are: presynaptic factors. including release probability and number of release sites; factors that determine synaptic GABA transients in the cleft, including diffusion and the actions of GABA transporters; and postsynaptic factors, including GABA, receptors subtypes, their location and number, their modulation by endogenous and exogenous factors, and their interactions with postsynaptic-anchoring proteins.
Generating diversity at GABAergic synapses / Cherubini, Enrico; Conti, F.. - In: TRENDS IN NEUROSCIENCES. - ISSN 0166-2236. - 24:3(2001), pp. 155-162. [10.1016/S0166-2236(00)01724-0]
Generating diversity at GABAergic synapses
Cherubini, Enrico;
2001-01-01
Abstract
GABA-mediated transmission is characterized by high variability of synaptic responses. Major contributors to this variability are: presynaptic factors. including release probability and number of release sites; factors that determine synaptic GABA transients in the cleft, including diffusion and the actions of GABA transporters; and postsynaptic factors, including GABA, receptors subtypes, their location and number, their modulation by endogenous and exogenous factors, and their interactions with postsynaptic-anchoring proteins.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
