Some people hear voices that others do not, but only some of those people seek treatment. Using a Pavlovian learning task, we induced conditioned hallucinations in four groups of people who differed orthogonally in their voice-hearing and treatment-seeking statuses. People who hear voices were significantly more susceptible to the effect. Using functional neuroimaging and computational modeling of perception, we identified processes that differentiated voice-hearers from non-voice-hearers and treatment-seekers from non-treatment-seekers and characterized a brain circuit that mediated the conditioned hallucinations. These data demonstrate the profound and sometimes pathological impact of top-down cognitive processes on perception and may represent an objective means to discern people with a need for treatment from those without.

Pavlovian conditioning-induced hallucinations result from overweighting of perceptual priors / Powers, A. R.; Mathys, Christoph Daniel; Corlett, P. R.. - In: SCIENCE. - ISSN 1095-9203. - 357:6351(2017), pp. 596-600. [10.1126/science.aan3458]

Pavlovian conditioning-induced hallucinations result from overweighting of perceptual priors

Mathys, Christoph Daniel;
2017-01-01

Abstract

Some people hear voices that others do not, but only some of those people seek treatment. Using a Pavlovian learning task, we induced conditioned hallucinations in four groups of people who differed orthogonally in their voice-hearing and treatment-seeking statuses. People who hear voices were significantly more susceptible to the effect. Using functional neuroimaging and computational modeling of perception, we identified processes that differentiated voice-hearers from non-voice-hearers and treatment-seekers from non-treatment-seekers and characterized a brain circuit that mediated the conditioned hallucinations. These data demonstrate the profound and sometimes pathological impact of top-down cognitive processes on perception and may represent an objective means to discern people with a need for treatment from those without.
2017
357
6351
596
600
https://www.academia.edu/34209499/Pavlovian_conditioning_induced_hallucinations_result_from_overweighting_of_perceptual_priors
Powers, A. R.; Mathys, Christoph Daniel; Corlett, P. R.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.11767/56281
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