Some people hear voices that others do not, but only some of those people seek treatment. Using a Pavlovian learning task, we induced conditioned hallucinations in four groups of people who differed orthogonally in their voice-hearing and treatment-seeking statuses. People who hear voices were significantly more susceptible to the effect. Using functional neuroimaging and computational modeling of perception, we identified processes that differentiated voice-hearers from non-voice-hearers and treatment-seekers from non-treatment-seekers and characterized a brain circuit that mediated the conditioned hallucinations. These data demonstrate the profound and sometimes pathological impact of top-down cognitive processes on perception and may represent an objective means to discern people with a need for treatment from those without.
|Titolo:||Pavlovian conditioning-induced hallucinations result from overweighting of perceptual priors|
|Autori:||Powers, A R; Mathys, C; Corlett, P R|
|Data di pubblicazione:||2017|
|Digital Object Identifier (DOI):||10.1126/science.aan3458|
|Appare nelle tipologie:||1.1 Journal article|