A fast computational framework is devised to the study of several configurations of patient-specific coronary artery bypass grafts. This is especially useful to perform a sensitivity analysis of the hemodynamics for different flow conditions occurring in native coronary arteries and bypass grafts, the investigation of the progression of the coronary artery disease and the choice of the most appropriate surgical procedure. A complete pipeline, from the acquisition of patient-specific medical images to fast parameterized computational simulations, is proposed. Complex surgical configurations employed in the clinical practice, such as Y-grafts and sequential grafts, are studied. A virtual surgery platform based on model reduction of unsteady Navier-Stokes equations for blood dynamics is proposed to carry out sensitivity analyses in a very rapid and reliable way. A specialized geometrical parameterization is employed to compare the effect of stenosis and anastomosis variation on the outcome of the surgery in several relevant cases.

Numerical modeling of hemodynamics scenarios of patient-specific coronary artery bypass grafts / Ballarin, Francesco; Faggiano, Elena; Manzoni, Andrea; Quarteroni, Alfio; Rozza, Gianluigi; Ippolito, Sonia; Antona, Carlo; Scrofani, Roberto. - In: BIOMECHANICS AND MODELING IN MECHANOBIOLOGY. - ISSN 1617-7959. - 16:4(2017), pp. 1373-1399. [10.1007/s10237-017-0893-7]

Numerical modeling of hemodynamics scenarios of patient-specific coronary artery bypass grafts

Ballarin, Francesco
;
Rozza, Gianluigi;
2017-01-01

Abstract

A fast computational framework is devised to the study of several configurations of patient-specific coronary artery bypass grafts. This is especially useful to perform a sensitivity analysis of the hemodynamics for different flow conditions occurring in native coronary arteries and bypass grafts, the investigation of the progression of the coronary artery disease and the choice of the most appropriate surgical procedure. A complete pipeline, from the acquisition of patient-specific medical images to fast parameterized computational simulations, is proposed. Complex surgical configurations employed in the clinical practice, such as Y-grafts and sequential grafts, are studied. A virtual surgery platform based on model reduction of unsteady Navier-Stokes equations for blood dynamics is proposed to carry out sensitivity analyses in a very rapid and reliable way. A specialized geometrical parameterization is employed to compare the effect of stenosis and anastomosis variation on the outcome of the surgery in several relevant cases.
2017
16
4
1373
1399
https://link.springer.com/article/10.1007%2Fs10237-017-0893-7
Ballarin, Francesco; Faggiano, Elena; Manzoni, Andrea; Quarteroni, Alfio; Rozza, Gianluigi; Ippolito, Sonia; Antona, Carlo; Scrofani, Roberto
File in questo prodotto:
File Dimensione Formato  
s10237-017-0893-7b.pdf

non disponibili

Tipologia: Versione Editoriale (PDF)
Licenza: Non specificato
Dimensione 6.22 MB
Formato Adobe PDF
6.22 MB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.11767/63595
Citazioni
  • ???jsp.display-item.citation.pmc??? 4
  • Scopus 33
  • ???jsp.display-item.citation.isi??? 28
social impact