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EnglishThe folding dynamics of proteins at the single-molecule level has been studied with single-molecule force spectroscopy experiments for 20 years, but a common standardized method for the analysis of the collected data and for sharing among the scientific community members is still not available. We have developed a new open-source tool—Fodis—for the analysis of the force-distance curves obtained in single-molecule force spectroscopy experiments, providing almost automatic processing, analysis, and classification of the obtained data. Our method provides also a classification of the possible unfolding pathways and the structural heterogeneity present during the unfolding of proteins.
Fodis: Software for Protein Unfolding Analysis / Galvanetto, Nicola; Perissinotto, Andrea; Pedroni, Andrea; Torre, Vincent. - In: BIOPHYSICAL JOURNAL. - ISSN 0006-3495. - 114:6(2018), pp. 1264-1266.
| Titolo: | Fodis: Software for Protein Unfolding Analysis |
| Autori: | Galvanetto, Nicola; Perissinotto, Andrea; Pedroni, Andrea; Torre, Vincent |
| Rivista: | |
| Data di pubblicazione: | 2018 |
| Volume: | 114 |
| Fascicolo: | 6 |
| Pagina iniziale: | 1264 |
| Pagina finale: | 1266 |
| Digital Object Identifier (DOI): | http://dx.doi.org/10.1016/j.bpj.2018.02.004 |
| Fulltext via DOI: | http://dx.doi.org/10.1016/j.bpj.2018.02.004 |
| URL: | http://www.sciencedirect.com/science/journal/00063495 https://doi.org/10.1016/j.bpj.2018.02.004 https://arxiv.org/abs/1803.11386 |
| Appare nelle tipologie: | 1.1 Journal article |
