Progress in the somatosensory field has been restricted by the limited number of genetic tools available to study gene function in peripheral sensory neurons. Here we generated a Cre-driver mouse line that expresses Cre-recombinase from the locus of the sensory neuron specific gene Advillin. These mice displayed almost exclusive Cre-mediated recombination in all peripheral sensory neurons. As such, the Advillin-Cre-driver line will be a powerful tool for targeting peripheral neurons in future investigations. © 2011 Zurborg et al; licensee BioMed Central Ltd.
Generation and characterization of an Advillin-Cre driver mouse line / Zurborg, Sandra; Piszczek, Agnieszka; Martínez, Conception; Hublitz, Philip; Al Banchaabouchi, Mumna; Moreira, Pedro; Perlas, Emerald; Heppenstall, Paul A.. - In: MOLECULAR PAIN. - ISSN 1744-8069. - 7:September(2011), pp. 1-10. [10.1186/1744-8069-7-66]
Generation and characterization of an Advillin-Cre driver mouse line
Heppenstall, Paul A.
2011-01-01
Abstract
Progress in the somatosensory field has been restricted by the limited number of genetic tools available to study gene function in peripheral sensory neurons. Here we generated a Cre-driver mouse line that expresses Cre-recombinase from the locus of the sensory neuron specific gene Advillin. These mice displayed almost exclusive Cre-mediated recombination in all peripheral sensory neurons. As such, the Advillin-Cre-driver line will be a powerful tool for targeting peripheral neurons in future investigations. © 2011 Zurborg et al; licensee BioMed Central Ltd.| File | Dimensione | Formato | |
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