TRPA1 is an ion channel expressed by nociceptors and activated by irritant compounds such as mustard oil. The endogenous function of TRPA1 has remained unclear, a fact highlighted by ongoing debate over its potential role as a sensor of noxious cold. Here we show that intracellular Ca2+ activates human TRPA1 via an EF-hand domain and that cold sensitivity occurs indirectly (and nonphysiologically) through increased [Ca2+] i during cooling in heterologous systems. © 2007 Nature Publishing Group.

Direct activation of the ion channel TRPA1 by Ca2+ / Zurborg, Sandra; Yurgionas, Brian; Jira, Julia A; Caspani, Ombretta; Heppenstall, Paul A.. - In: NATURE NEUROSCIENCE. - ISSN 1097-6256. - 10:3(2007), pp. 277-279. [10.1038/nn1843]

Direct activation of the ion channel TRPA1 by Ca2+

Heppenstall, Paul A.
2007

Abstract

TRPA1 is an ion channel expressed by nociceptors and activated by irritant compounds such as mustard oil. The endogenous function of TRPA1 has remained unclear, a fact highlighted by ongoing debate over its potential role as a sensor of noxious cold. Here we show that intracellular Ca2+ activates human TRPA1 via an EF-hand domain and that cold sensitivity occurs indirectly (and nonphysiologically) through increased [Ca2+] i during cooling in heterologous systems. © 2007 Nature Publishing Group.
10
3
277
279
https://www.nature.com/articles/nn1843
Zurborg, Sandra; Yurgionas, Brian; Jira, Julia A; Caspani, Ombretta; Heppenstall, Paul A.
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/20.500.11767/87828
Citazioni
  • ???jsp.display-item.citation.pmc??? 214
  • Scopus 403
  • ???jsp.display-item.citation.isi??? 367
social impact