TRPA1 is an ion channel expressed by nociceptors and activated by irritant compounds such as mustard oil. The endogenous function of TRPA1 has remained unclear, a fact highlighted by ongoing debate over its potential role as a sensor of noxious cold. Here we show that intracellular Ca2+ activates human TRPA1 via an EF-hand domain and that cold sensitivity occurs indirectly (and nonphysiologically) through increased [Ca2+] i during cooling in heterologous systems. © 2007 Nature Publishing Group.

Direct activation of the ion channel TRPA1 by Ca2+ / Zurborg, Sandra; Yurgionas, Brian; Jira, Julia A; Caspani, Ombretta; Heppenstall, Paul A.. - In: NATURE NEUROSCIENCE. - ISSN 1097-6256. - 10:3(2007), pp. 277-279. [10.1038/nn1843]

Direct activation of the ion channel TRPA1 by Ca2+

Heppenstall, Paul A.
2007-01-01

Abstract

TRPA1 is an ion channel expressed by nociceptors and activated by irritant compounds such as mustard oil. The endogenous function of TRPA1 has remained unclear, a fact highlighted by ongoing debate over its potential role as a sensor of noxious cold. Here we show that intracellular Ca2+ activates human TRPA1 via an EF-hand domain and that cold sensitivity occurs indirectly (and nonphysiologically) through increased [Ca2+] i during cooling in heterologous systems. © 2007 Nature Publishing Group.
2007
10
3
277
279
https://www.nature.com/articles/nn1843
Zurborg, Sandra; Yurgionas, Brian; Jira, Julia A; Caspani, Ombretta; Heppenstall, Paul A.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.11767/87828
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