TRPA1 is an ion channel expressed by nociceptors and activated by irritant compounds such as mustard oil. The endogenous function of TRPA1 has remained unclear, a fact highlighted by ongoing debate over its potential role as a sensor of noxious cold. Here we show that intracellular Ca2+ activates human TRPA1 via an EF-hand domain and that cold sensitivity occurs indirectly (and nonphysiologically) through increased [Ca2+] i during cooling in heterologous systems. © 2007 Nature Publishing Group.
|Titolo:||Direct activation of the ion channel TRPA1 by Ca2+|
|Autori:||Zurborg, Sandra; Yurgionas, Brian; Jira, Julia A; Caspani, Ombretta; Heppenstall, Paul A.|
|Data di pubblicazione:||2007|
|Digital Object Identifier (DOI):||10.1038/nn1843|
|Appare nelle tipologie:||1.1 Journal article|