In recent years, the use of free-standing carbon nanotube (CNT) films for neural tissue-engineering have attracted tremendous attention. CNT films show large surface area and high electrical conductivity that combined to flexibility and biocompatibility may promote neuron growth and differentiation while stimulating neural activity. Besides, adhesion, survival, and growth of neurons can be modulated through chemical modification of CNTs. Axonal and synaptic signaling can also be positively tuned by these materials. Here we describe the ability of free-standing CNT films to influence neuronal activity. We demonstrate that the degree of crosslinking between the CNTs has a strong impact on the electrical conductivity of the substrate, which, in turn, regulates neural circuit outputs.

Chemically Cross-Linked Carbon Nanotube Films Engineered to Control Neuronal Signaling / Barrejón, Myriam; Rauti, Rossana; Ballerini, Laura; Prato, Maurizio. - In: ACS NANO. - ISSN 1936-0851. - 13:8(2019), pp. 8879-8889. [10.1021/acsnano.9b02429]

Chemically Cross-Linked Carbon Nanotube Films Engineered to Control Neuronal Signaling

Rauti, Rossana;Ballerini, Laura
;
2019-01-01

Abstract

In recent years, the use of free-standing carbon nanotube (CNT) films for neural tissue-engineering have attracted tremendous attention. CNT films show large surface area and high electrical conductivity that combined to flexibility and biocompatibility may promote neuron growth and differentiation while stimulating neural activity. Besides, adhesion, survival, and growth of neurons can be modulated through chemical modification of CNTs. Axonal and synaptic signaling can also be positively tuned by these materials. Here we describe the ability of free-standing CNT films to influence neuronal activity. We demonstrate that the degree of crosslinking between the CNTs has a strong impact on the electrical conductivity of the substrate, which, in turn, regulates neural circuit outputs.
2019
13
8
8879
8889
Barrejón, Myriam; Rauti, Rossana; Ballerini, Laura; Prato, Maurizio
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.11767/98816
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