We analyzed the mouse Representative Transcript and Protein Set for molecules involved in brain function.We found full-length cDNAs of many known brain genes and discovered new members of known brain gene families, including Family 3 G-protein coupled receptors, voltage-gated channels, and connexins.We also identified previously unknown candidates for secreted neuroactive molecules.The existence of a large number of unique brain ESTs suggests an additional molecular complexity that remains to be explored.A list of genes containing CAG stretches in the coding region represents a first step in the potential identification of candidates for hereditary neurological disorders.

Analysis of the mouse transcriptome for genes involved in the function of the nervous system / Gustincich, S.; Batalov, S.; Beisel, K. W.; Bono, H.; Carninci, P.; Fletcher, C. F.; Grimmond, S.; Hirokawa, N.; Jarvis, E. D.; Jegla, T.; Kawasawa, Y.; Lemieux, J.; Miki, H.; Raviola, E.; Teasdale, R. D.; Tominaga, N.; Yagi, K.; Zimmer, A.; Arakawa, T.; Waki, K.; Kawai, J.; Hayashizaki, Y.; Okazaki, Y.. - In: GENOME RESEARCH. - ISSN 1088-9051. - 13:6B(2003), pp. 1395-1401. [10.1101/gr.1135303]

Analysis of the mouse transcriptome for genes involved in the function of the nervous system

Gustincich, S.;
2003-01-01

Abstract

We analyzed the mouse Representative Transcript and Protein Set for molecules involved in brain function.We found full-length cDNAs of many known brain genes and discovered new members of known brain gene families, including Family 3 G-protein coupled receptors, voltage-gated channels, and connexins.We also identified previously unknown candidates for secreted neuroactive molecules.The existence of a large number of unique brain ESTs suggests an additional molecular complexity that remains to be explored.A list of genes containing CAG stretches in the coding region represents a first step in the potential identification of candidates for hereditary neurological disorders.
2003
13
6B
1395
1401
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC403671/
Gustincich, S.; Batalov, S.; Beisel, K. W.; Bono, H.; Carninci, P.; Fletcher, C. F.; Grimmond, S.; Hirokawa, N.; Jarvis, E. D.; Jegla, T.; Kawasawa, Y...espandi
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.11767/16230
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