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EnglishThe binding capability of three ruthenium polypyridyl compounds of structural formula [Ru(apy)(tpy)Ln-](ClO4)((2-n)) [1a-c; apy = 2,2'-azobis(pyridine), tpy = 2,2':6',2 ''-terpyridine, L = Cl, H2O, CH3CN] to a fragment of DNA was studied. The interaction between each of these complexes and the DNA model base 9-ethylguanine (9-EtGua) was followed by means of H-1 NMR studies. Density functional theory calculations were carried out to explore the preferential ways of coordination between the ruthenium complexes and guanine. The ruthenium-9-EtGua adduct formed was isolated and fully characterized using different techniques. A variable-temperature H-1 NMR experiment was carried out that showed that while the 9-EtGua fragment was rotating fast at high temperature, a loss of symmetry was suffered by the model base adduct as the temperature was lowered, indicating restricted rotation of the guanine residue.
Interaction between the DNA model base 9-ethylguanine and a group of ruthenium polypyridyl complexes: Kinetics and conformational temperature dependence / Corral, E; Hotze, Acg; Magistrato, Alessandra; Reedijk, J.. - In: INORGANIC CHEMISTRY. - ISSN 0020-1669. - 46:16(2007), pp. 6715-6722. [10.1021/ic070092u]
| Titolo: | Interaction between the DNA model base 9-ethylguanine and a group of ruthenium polypyridyl complexes: Kinetics and conformational temperature dependence | |
| Autori: | Corral, E; Hotze, Acg; Magistrato, Alessandra; Reedijk, J. | |
| Rivista: | ||
| Data di pubblicazione: | 2007 | |
| Volume: | 46 | |
| Fascicolo: | 16 | |
| Pagina iniziale: | 6715 | |
| Pagina finale: | 6722 | |
| Digital Object Identifier (DOI): | http://dx.doi.org/10.1021/ic070092u | |
| Appare nelle tipologie: | 1.1 Journal article |
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