Olfactory sensory neurons (OSNs) use a Ca2+-activated Clˉ channels amplification mechanism in olfactory transduction. Odor binding to odorant receptors in the cilia of OSNs leads to an increase of intraciliary Ca2+ concentration by Ca2+ entry through cyclic nucleotide-gated channels. Ca2+ activates a Clˉ channel that leads to an efflux of Clˉ from the cilia, contributing to the depolarization in OSNs...
|Autori interni:||Sagheddu, Claudia|
|Titolo:||Functional characterization of molecular candidates for the calcium-activated chloride channels in the cilia of olfactory sensory neurons|
|Data di pubblicazione:||17-dic-2010|
|Appare nelle tipologie:||8.1 PhD thesis|