8 Thesis

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Nanoscale single-cell interfaces allow optical activation of single neurons and sensory-motor modulation in organotypic slices

Nano-technology based tools are allowing neuroscientists to precisely and selectively stimulate and investigate neuronal circuits, with unprecedented accuracy. However, the existing neuron-stimulating interfaces engineered at the nano-scale level are usually facing compromises between being less-invasive or yielding a higher level of specificity. To provide single-cell stimulation, current nano-electronic devices are precise and powerful but exert stressful harm over the targeted ne...

Papillomavirus as a novel viral vector for ex vivo gene therapy of the skin

Ex vivo gene delivery to the skin utilizing retroviral vectors has been demonstrated to be a viable clinical option for the replacement of defective genes. However, because these vectors integrate their cargo into the genome, safety issues arise when utilizing them to deliver gene-editing nucleases. Here, we explored the use of Papillomavirus, a non-integrating viral vector that can deliver up to 8 kilobases of double stranded DNA, for ex vivo skin gene editing, exploiting its natural tropism...

Applications of Grothendieck-Riemann-Roch theorem for stacks and stringy Chow ring of weighted blow-ups

In this thesis we prove three results. Firstly we apply the Grothendieck-Riemann-Roch theorem for stacks to root stacks to rederive the formula for parabolic bundles. Next we apply the same theorem to a quotient stack to derive a formula for equivariant Euler characteristic. When the quotient is obtained by an action on a smooth projective curve, we explicitly compute the Euler characteristic in terms of ramification data. This agrees with many previous results with different levels of genera...

Feature selection by Information Imbalance optimization: Clinics, molecular modeling and ecology

In feature selection current methods are often limited by the types and dimensions of data they can handle. Supervised methods, in particular, are rigid regarding their target space, typically requiring it to be one-dimensional and of a specific type (e.g. continuous or categorical). This thesis introduces feature selection methods which mitigate these limitations using a statistic called the Information Imbalance. This method identifies a low-dimensional subset of input features that best ...

Non-cognitive factors influencing numeracy in higher education

The promotion of numeracy across the lifespan is a key objective for many national and international institutions, given its importance at both individual and societal levels. In my dissertation, I sought to deepen our understanding of the role that non-cognitive factors, particularly math anxiety and personality, play in numeracy in higher education, taking into account gender differences the varying math content of different fields of study. I conducted four empirical studies, assessing num...

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8 Thesis: [2348] Home page macrotipologia

Prodotti recenti

Nanoscale single-cell interfaces allow optical activation of single neurons and sensory-motor modulation in organotypic slices

Papillomavirus as a novel viral vector for ex vivo gene therapy of the skin

Applications of Grothendieck-Riemann-Roch theorem for stacks and stringy Chow ring of weighted blow-ups

Feature selection by Information Imbalance optimization: Clinics, molecular modeling and ecology

Non-cognitive factors influencing numeracy in higher education

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Accesso al fulltext

SISSA DIGITAL LIBRARYInstitutional Research Information System (Statistiche: prodotti, OA)Per informazioni contatta sdl@sissa.it

8 Thesis: [2348] Home page macrotipologia

Prodotti recenti

Nanoscale single-cell interfaces allow optical activation of single neurons and sensory-motor modulation in organotypic slices

Papillomavirus as a novel viral vector for ex vivo gene therapy of the skin

Applications of Grothendieck-Riemann-Roch theorem for stacks and stringy Chow ring of weighted blow-ups

Feature selection by Information Imbalance optimization: Clinics, molecular modeling and ecology

Non-cognitive factors influencing numeracy in higher education

Scopri

Tipologia

Autore

Data di pubblicazione

Editore

Settore disciplinare

Keyword

Lingua

Accesso al fulltext

SISSA DIGITAL LIBRARYInstitutional Research Information System (Statistiche: prodotti, OA)
Per informazioni contatta sdl@sissa.it