Prion diseases are a group of invariably fatal disorders, for which there is no cure. Despite their rare incidence in humans, prion diseases have captured very large attention from the scientific community due to the unconventional mechanism by which they are transmitted.1 The central feature of prion diseases is the accumulation in the brain and some other tissues of the diseaseassociated PrPSc, which is derived from the host-encoded cellular PrPC.1 The conversion from a normal form (PrPC) to an infectious isoform (scrapie, PrPSc) is triggered by the interaction between PrPC-PrPSc,2 as well as protein-protein interaction (PPI).3....
Design, synthesis and molecular modeling studies of drug candidate compounds against prion diseases / Bongarzone, Salvatore. - (2011 Sep 09).
Design, synthesis and molecular modeling studies of drug candidate compounds against prion diseases
Bongarzone, Salvatore
2011-09-09
Abstract
Prion diseases are a group of invariably fatal disorders, for which there is no cure. Despite their rare incidence in humans, prion diseases have captured very large attention from the scientific community due to the unconventional mechanism by which they are transmitted.1 The central feature of prion diseases is the accumulation in the brain and some other tissues of the diseaseassociated PrPSc, which is derived from the host-encoded cellular PrPC.1 The conversion from a normal form (PrPC) to an infectious isoform (scrapie, PrPSc) is triggered by the interaction between PrPC-PrPSc,2 as well as protein-protein interaction (PPI).3....| File | Dimensione | Formato | |
|---|---|---|---|
|
1963_6293_PhD_Thesis_Bongarzone_Salvatore.pdf
accesso aperto
Tipologia:
Tesi
Licenza:
Non specificato
Dimensione
16.46 MB
Formato
Adobe PDF
|
16.46 MB | Adobe PDF | Visualizza/Apri |
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
